PPI Test in GP Patients

The Proton Pump Inhibitor Test in Reflux Disease: a Study Using Nexium in General Practice Patients

The purpose of this study is to determine the diagnostic value of two week treatment with Nexium as a confirmatory test for patients with suspected reflux disease.

Inclusion Criteria:

• Age ≥ 18 years
• Symptoms suggestive for gastric acid reflux disease during 2 or more days per week

Exclusion Criteria:

• Treatment with prokinetic or acid secretion inhibitors within 4 weeks prior to inclusion
• Treatment with a PPI for more than 30 days within the last 3 months prior to inclusion
• History of proven peptic ulcer disease, unless successfully treated with Helicobacter pylori eradication longer than 1 month before inclusion