The Association of Breast Density Changes, Plasma Hormone Changes, and Breast Cancer Recurrence: A Companion Study to NCIC CTG MA.27
The Association of Breast Density Changes, Plasma Hormone Changes, and Breast Cancer Recurrence: A Companion Study to NCIC CTG MA.27
RATIONALE: Understanding the relationship between breast density, levels of hormones in the blood, and levels of anticancer drugs in the blood may help improve the ability to plan effective treatment for women with invasive breast cancer.
PURPOSE: This clinical trial is studying the relationship between breast density and blood levels of hormones and anticancer drugs in women with invasive breast cancer who are receiving exemestane or anastrozole.
OBJECTIVES:
Primary
Secondary
OUTLINE: This is a multicenter, companion study.
Patients complete a 10-minute questionnaire about factors that might affect changes in breast density at baseline and another questionnaire at 1 year and 2 years post registration. Blood samples are collected at baseline (before initiation of treatment ) and at 1 year post registration for hormone and drug level analysis. Mammograms taken prior to registration (within 12 months prior to enrollment) and at approximately 1 and 2 years post-registration to this study are retrieved and digitized for determination of percent breast density and dense area.
PROJECTED ACCRUAL: A total of 550 patients will be accrued for this study.
DISEASE CHARACTERISTICS:
Histologically confirmed invasive breast cancer
Completely resected disease
One intact, noncancerous breast with no prior breast surgery in that breast except breast biopsy
Estrogen receptor- and/or progesterone receptor-positive tumor
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Fairbanks, Alaska 99701, United States
Fort Smith, Arkansas 72903, United States
Little Rock, Arkansas 72205, United States
Los Angeles, California 90089-9181, United States
Palm Springs, California 92262, United States
San Francisco, California 94115, United States
Santa Clara, California 95051, United States
South San Francisco, California 94080, United States
Pensacola, Florida 32514, United States
Ottawa, Illinois 61350, United States
Peoria, Illinois 61615, United States
Beech Grove, Indiana 46107, United States
La Porte, Indiana 46350, United States
Wichita, Kansas 67214, United States
Louisville, Kentucky 40202, United States
Lewiston, Maine 04240, United States
Baltimore, Maryland 21201, United States
Boston, Massachusetts 02115, United States
St Louis, Missouri 63110, United States
Billings, Montana 59101, United States
Missoula, Montana 59807, United States
Concord, New Hampshire 03301, United States
Keene, New Hampshire 03431, United States
Flemington, New Jersey 08822, United States
Marlton, New Jersey 08053, United States
Morristown, New Jersey 07962, United States
Voorhees Township, New Jersey 08043, United States
The Bronx, New York 10461, United States
Charlotte, North Carolina 28233-3549, United States
Pinehurst, North Carolina 28374, United States
Wright-Patterson Air Force Base, Ohio 45433-5529, United States
Hershey, Pennsylvania 17033-0850, United States
Wilkes-Barre, Pennsylvania 18711, United States
Spartanburg, South Carolina 29303, United States
Burlington, Vermont 05401, United States
Seattle, Washington 98195-6043, United States
Green Bay, Wisconsin 54301-3526, United States
La Crosse, Wisconsin 54601, United States
Madison, Wisconsin 53792-6164, United States
Wausau, Wisconsin 54401, United States