This study is for patients with metastatic adenocarcinoma arising from the colon or rectum who have received treatment(s) for metastatic disease with subsequent disease progression. Patients who are intolerant to treatment(s) are also included. This is a study for good performance status colorectal cancer patients who have exhausted standard therapy options.

Inclusion Criteria:

• Radiographic evidence of metastatic, progressive disease following standard therapies.
• Eastern Cooperative Oncology Group (ECOG) performance status 0-1.

Exclusion Criteria:

• Known brain metastases or uncontrolled pleural effusions.
• History of chronic inflammatory or autoimmune disease.