See Termination Reason in Detailed Description.

To assess the efficacy and safety of PF-3512676 administered in combination with paclitaxel, carboplatin and bevacizumab as first-line treatment in patients with locally advanced or metastatic nonsquamous non-small cell lung cancer

PF-3512676 dosing was stopped 21 June 2007 when Pfizer decided to stop the administration of PF-3512676 in all trials which combined PF-3512676 with cytotoxic chemotherapy. the decision was made subsequent to DSMC recommendation to close two phase III randomized trials in non-small cell lung cancer which also combined PF-3512676 with cytotoxic chemotherapy, citing lack of efficacy concerns as the primary reason with safety issues (sepsis, thrombocytopenia) also contributing to the decision. Subjects were allowed to complete standard of care treatment/survival follow-up. Data collection was completed on 22 May 2008.

Inclusion Criteria:

• Advanced Stage IIIb with pleural effusion or Stage IV nonsquamous non-small cell lung cancer
• ECOG Performance Status 0-1
• Measurable disease per RECIST criteria

Exclusion Criteria:

• Squamous cell, small cell, or carcinoid lung cancer
• CNS metastasis
• Pre-existing autoimmune or antibody mediated disease
• Prior systemic treatment for NSCLC with chemo, immunotherapy, biologics, or investigation drugs