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Poor enrollment
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| Name | Class |
|---|---|
| The Physicians' Services Incorporated Foundation | OTHER |
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The purpose of this study is to compare two methods of delivering Nasal Continuous Airway Pressure (NCPAP): Biphasic Mode and a continuous mode, to see which is better in getting babies off the ventilator and decreasing lung damage.
Chronic lung disease (CLD) remains a significant problem among low birth weight infants with a reported incidence of up to 26% in infants < 1500 grams. Nasal continuous positive airway pressure (NCPAP) has been demonstrated to provide effective non-invasive respiratory support for preterm infants. The use of NCPAP is associated with a decreased need for mechanical ventilation and may impact on the incidence of CLD. There are two types of NCPAP now available, a Biphasic mode which allows for cycling at two different levels of positive pressure and a continuous mode which allows only for one level of positive pressure.
Comparisons: Biphasic NCPAP will be compared with continuous CPAP to see which better facilitates the extubation of preterm infants who weigh \
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Biphasic NCPAP |
|
| 2 | Active Comparator | Continuous CPAP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biphasic Infant flow NCPAP | Procedure | Biphasic Nasal continuous positive airway pressure |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The rate of successful extubation with either mode of NCPAP | Day 7 post primary extubation |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of chronic lung disease | ||
| The incidence of other complications of prematurity including sepsis,retinopathy of prematurity, intraventricular haemorrhage/periventricular leucomalacia and necrotizing entercolitis |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Karel O'Brien, MB, FRCPC | MOUNT SINAI HOSPITAL | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mount Sinai Hospital | Toronto | Ontario | M5G1X5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22475409 | Derived | O'Brien K, Campbell C, Brown L, Wenger L, Shah V. Infant flow biphasic nasal continuous positive airway pressure (BP- NCPAP) vs. infant flow NCPAP for the facilitation of extubation in infants' </= 1,250 grams: a randomized controlled trial. BMC Pediatr. 2012 Apr 4;12:43. doi: 10.1186/1471-2431-12-43. |
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| CPAP |
| Procedure |
Continuous positive airway pressure |
|
| The predictive value of the minute ventilation test |
| ID | Term |
|---|---|
| D007235 | Infant, Premature, Diseases |
| D001997 | Bronchopulmonary Dysplasia |
| D001049 | Apnea |
| ID | Term |
|---|---|
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D055397 | Ventilator-Induced Lung Injury |
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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