Comparing the Effect of Under the Tongue Olanzapine Versus Swallowed Olanzapine on Body Mass Index (A Ratio of Weight to Height)

BMI Evaluation: Placebo and Active Comparator Trial of Olanzapine Zydis Pills Used Sublingually (PLATYPUS)

This study is testing if under the tongue olanzapine for schizophrenia, related psychosis, schizoaffective disorder or bipolar disorder will have less weight gain than olanzapine that is swallowed, in patients who are already gaining weight on olanzapine.

Inclusion Criteria (Patients must):

• Be at least 18 years old
• Have gained weight while taking olanzapine
• Be able to visit the doctor's office seven times over 4 months (17 weeks)

Exclusion Criteria (Patients must NOT):

• Have started a weight loss program within the last 8 weeks
• Have an illness that might affect patient's weight during the study
• Have an allergy to phenylalanine, mannitol or saccharine
• Be taking any medication (except for olanzapine) that might affect patient's weight