This study looks at the causes of anemia in adults of all ages who are referred by their primary care physician.

This study is being done to determine if the range of causes of anemia changes with advancing age. The goal of this study is to apply research methods to see if causes of anemia can be determined in patients where a clear cause is not found with routine clinical testing available to all patients in physician offices.

Participants in this study will be evaluated at the NIA-ASTRA unit at Harbor Hospital in Baltimore. Testing will consist of both diagnostic and research blood and urine testing along with history and physical exam. An optional bone marrow aspirate or aspirate and biopsy may be performed if the patient permits and it is indicated for either research or clinical diagnostic purposes. All study information supporting a specific diagnosis will be provided to the patient and, at their request, to their primary care physician if specific treatment is indicated.

Inclusion Criteria:

• 18 years of age or older
• Hemoglobin (Hgb) less than 13 in males and females

Exclusion Criteria:

• Pregnant or nursing women
• Participation within the past six weeks in another research study which the Principal Investigator believes is incompatible with this study

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