Efficacy and Safety of Colistin for Therapy of Infections Caused by ESBL Producing K.Pneumoniae or E.Coli

Efficacy and Safety of Colistin for Therapy of Infections Caused by Extended Spectrum Beta-Lactamase(ESBL) Producing Klebsiella Pneumoniae or Escherichia Coli

In patients with documented ESBL-producing E.coli and Klebsiella pneumoniae will be allocated to receive colistin or conventional antibiotic regimen.

In patients with documented ESBL-producing E.coli and Klebsiella pneumoniae will be allocated to receive colistin or conventional antibiotic regimen.The primary outcome is clinical response and secondary outcomes are microbiological response and adverse events.

Inclusion Criteria:

• Age > 18 yr.
• Hospitalized to Siriraj Hospital
• Infections with ESBL-producing E.coli or K.pneumoniae
• Consent informed consent

Exclusion Criteria:

• Pregnancy or lactating mother
• Colistin allergy
• Neurologic diseases