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| ID | Type | Description | Link |
|---|---|---|---|
| SMRI grant # 01T-404 |
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| Name | Class |
|---|---|
| Stanley Medical Research Institute | OTHER |
We investigate whether the add-on specific antitoxoplasmatic medication has positive effects in individuals with schizophrenia or major depression seropositive for Toxoplasma gondii (TG) infection. As TG modulates neurotransmitter metabolism affecting serotonin and dopamine we hypothesize that this chronic persistent infection might play a role for depressive and psychotic symptomatology. Therefore, on the basis of an ex juvantibus approach, specific anti TG medication might further improve psychiatric symptomatology in affected patients. This is investigated in a double-blind, placebo-controlled, randomized treatment trial.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| daraprim | Drug | |||
| pyrimethamine | Drug | |||
| folinic acid | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Psychopathology ratings |
| Measure | Description | Time Frame |
|---|---|---|
| TG infection parameters |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dunja Hinze-Selch, MD | Zentrum für Integrative Psychiatrie | Principal Investigator |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D003865 | Depressive Disorder, Major |
| D011618 | Psychotic Disorders |
| D003863 | Depression |
| D019964 | Mood Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D003866 | Depressive Disorder |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D011739 | Pyrimethamine |
| D002955 | Leucovorin |
| ID | Term |
|---|---|
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D005575 | Formyltetrahydrofolates |
| D013763 | Tetrahydrofolates |
| D005492 | Folic Acid |
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D003067 | Coenzymes |
| D045762 | Enzymes and Coenzymes |
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