Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery

Randomized Multicenter Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery: Single-Dose Vs. Three Doses of Second-Generation Cephalosporin

To determine the optimal prophylactic antibiotics administration method in elective colorectal surgery

Use of prophylactic antibiotics in elective colorectal surgery is essential. Although single-dose prophylactic antibiotics are recommended, the efficacy of single-dose cephalosporin without metronidazole and oral antibiotics is not fully proven. We conducted a multicenter randomized trial of single-dose vs. three doses of the second-generation cephalosporin, cefmetazole.

Inclusion Criteria:

• Colorectal diseases (cancer, large polyp, carcinoid, lymphoma,sarcoma and so on)
• Elective colorectal resection

Exclusion Criteria:

• Emergent operation
• Ileus
• No resection
• Preoperative infectious diseases
• Penicillin or cephalosporin allergy
• Antibiotics administration before surgery
• Inflammatory bowel diseases
• Angina or myocardial infarction
• Renal dysfunction
• Diabetes mellitus
• Steroid administration before surgery