Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis

Simvastatin Effect on Endothelium Dependent Venodilation in Chronic Renal Failure Patients Treated by Peritoneal Dialysis

This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.

This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.

Inclusion Criteria:

• end stage renal failure
• peritoneal dialysis
• LDL cholesterol > 100mg/dL
• > 18 years and < 80 years

Exclusion Criteria:

• using statin or nitrate
• liver disease
• diabetes mellitus