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| ID | Type | Description | Link |
|---|---|---|---|
| ABCSG 8 |
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The purpose of this study is to assess the difference in event-free survival between postmenopausal women with hormone receptor-positive early breast cancer who switched from tamoxifen to anastrozole and those who continued to receive tamoxifen.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tamoxifen | Drug | |||
| Anastrozole | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| To assess the difference in event free survival and overall survival (subject to stand-alone or combined/meta-analysis) between postmenopausal women with HR +ve early BC who switched from tamoxifen to anastrozole and those who continued on tamoxifen. |
| Measure | Description | Time Frame |
|---|---|---|
| To assess the difference in event free survival & overall survival (subject to stand-alone or combined/meta-analysis) plus side effects between postmenopausal women with HR+ve early BC who switched from tam to anastrozole and those who continued on tam. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Raimund Jakesz, MD | Austrian Breast & Colorectal Cancer Study Group | Principal Investigator |
| AstraZeneca Austria Medical Director, MD | AstraZeneca | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Amstetten | Austria | ||||
| Research Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25332252 | Derived | Sestak I, Cuzick J, Dowsett M, Lopez-Knowles E, Filipits M, Dubsky P, Cowens JW, Ferree S, Schaper C, Fesl C, Gnant M. Prediction of late distant recurrence after 5 years of endocrine treatment: a combined analysis of patients from the Austrian breast and colorectal cancer study group 8 and arimidex, tamoxifen alone or in combination randomized trials using the PAM50 risk of recurrence score. J Clin Oncol. 2015 Mar 10;33(8):916-22. doi: 10.1200/JCO.2014.55.6894. Epub 2014 Oct 20. | |
| 24347518 |
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| Bad Ischl |
| Austria |
| Research Site | Baden | Austria |
| Research Site | Bregenz | Austria |
| Research Site | Bruck/Mur | Austria |
| Research Site | Dornbirn | Austria |
| Research Site | Eisenstadt | Austria |
| Research Site | Feldbach | Austria |
| Research Site | Feldkirch | Austria |
| Research Site | Freistadt | Austria |
| Research Site | FĂĽrstenfeld | Austria |
| Research Site | GmĂĽnd | Austria |
| Research Sites | Graz | Austria |
| Research Site | Guessing | Austria |
| Research Site | Hainburg an der Donau | Austria |
| Research Site | Hartberg | Austria |
| Research Site | Hollabrunn | Austria |
| Research Site | Horn | Austria |
| Research Site | Innsbruck | Austria |
| Research Site | Judenburg | Austria |
| Research Site | Kirchdorf | Austria |
| Research Site | Klagenfurt | Austria |
| Research Sites | Klosterneuburg | Austria |
| Research Site | Kufstein | Austria |
| Research Site | Leoben | Austria |
| Research Sites | Linz | Austria |
| Research SIte | Melk | Austria |
| Research Site | Mistelbach | Austria |
| Research Site | Mödling | Austria |
| Research Site | Neunkirchen | Austria |
| Research Site | Oberpullendorf | Austria |
| Research Site | Oberwart | Austria |
| Research Site | Ried im Innkreis | Austria |
| Research Site | Rohrbach | Austria |
| Research Site | Rottenmann | Austria |
| Research Site | Saint Poelton | Austria |
| Research Site | Saint Veit/Glan | Austria |
| Research Site | Salzburg | Austria |
| Research Site | Schaerding | Austria |
| Research Site | Scheibbs | Austria |
| Research Site | Schladming | Austria |
| Research Site | Schwarzach/Pongau | Austria |
| Research Site | Spittal/Drau | Austria |
| Research Site | Steyr | Austria |
| Research Site | Tulln | Austria |
| Research Sites | Vienna | Austria |
| Research Site | Villach | Austria |
| Research Site | Vöcklabruck | Austria |
| Research Site | Waidhofen/Thaya | Austria |
| Research Site | Wels | Austria |
| Research Site | Wolfsberg | Austria |
| Research Site | Zams | Austria |
| Derived |
| Gnant M, Filipits M, Greil R, Stoeger H, Rudas M, Bago-Horvath Z, Mlineritsch B, Kwasny W, Knauer M, Singer C, Jakesz R, Dubsky P, Fitzal F, Bartsch R, Steger G, Balic M, Ressler S, Cowens JW, Storhoff J, Ferree S, Schaper C, Liu S, Fesl C, Nielsen TO; Austrian Breast and Colorectal Cancer Study Group. Predicting distant recurrence in receptor-positive breast cancer patients with limited clinicopathological risk: using the PAM50 Risk of Recurrence score in 1478 postmenopausal patients of the ABCSG-8 trial treated with adjuvant endocrine therapy alone. Ann Oncol. 2014 Feb;25(2):339-45. doi: 10.1093/annonc/mdt494. Epub 2013 Dec 16. |
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D013629 | Tamoxifen |
| D000077384 | Anastrozole |
| ID | Term |
|---|---|
| D013267 | Stilbenes |
| D001597 | Benzylidene Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D009570 | Nitriles |
| D014230 | Triazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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