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| Name | Class |
|---|---|
| Novo Nordisk A/S | INDUSTRY |
We sought to determine if there is a benefit to using an insulin drip to control hyperglycemia in the surgical critical care unit for patients who undergo general and vascular surgery.
While evidence exists for using tight glycemic control in the critically ill cardiac surgical patient, other patient populations have yet to be studied. We performed a prospective randomized trial for using intensive insulin therapy in the general and vascular critically ill surgical patient population. We will compare tight glycemic control versus conventional glycemic control to determine if there is a benefit to the normalization of blood glucose levels in this patient population
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Novolin R (human recombinant Insulin) | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality |
| Measure | Description | Time Frame |
|---|---|---|
| Length of ICU Stay | ||
| Ventilatory Requirement | ||
| Vasopressor Support |
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Inclusion Criteria: Patients undergoing a general or vascular surgical procedure requiring admission to the surgical intensive care unit as a result of ventilatory requirement, vasopressor support, or physiologic instability
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael Kia, DO | Ascension Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Genesys Regional Medical Center | Grand Blanc | Michigan | 48439 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11794168 | Background | van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67. doi: 10.1056/NEJMoa011300. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D012131 | Respiratory Insufficiency |
| D051437 | Renal Insufficiency |
| D013530 | Surgical Wound Infection |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D007328 | Insulin |
| ID | Term |
|---|---|
| D011384 | Proinsulin |
| D061385 | Insulins |
| D010187 | Pancreatic Hormones |
| D036361 | Peptide Hormones |
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| Incidence of Renal Failure |
| Incidence of Wound Infection |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D014946 | Wound Infection |
| D011183 | Postoperative Complications |
| D006728 |
| Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |