Study Comparing Conversion From Calcineurin Inhibitors to Rapamune Versus Standard Therapy in Established Renal Allograft Recipients

A Multi-centre, Randomized, Open-label, Study to Compare Conversion From Calcineurin Inhibitors to Rapamune Versus Standard Therapy in Established Renal Allograft Recipients on Maintenance Therapy With Mild to Moderate Renal Insufficiency.

The purpose of the study is to determine the effect of conversion from calcineurin inhibitor based therapy to Rapamune based therapy in patients with mild to moderate renal insufficiency.

Inclusion Criteria:

• Age over 18
• Treatment with a calcineurin inhibitor
• Patients with mild to moderate renal insufficiency

Exclusion Criteria:

• Patients with acute rejection
• Patients who received a transplant more than 10 years ago