Effect of Budesonide / Formoterol Combination in Repeated AMP Provocations

A Randomized Double Blind Comparison Between Single Doses of Symbicort Turbuhaler (Budesonide/Formoterol Combination), Formoterol, Salbutamol and Placebo in Repeated AMP-challenges in Patients With Mild - to Moderate Asthma. Investigating the Supplementary Value of the Budesonide Component Within Symbicort When Tested in a Model of Slow Onset Acute Asthma

The aim is to study whether the budesonide component within the budesonide/ formoterol combination inhaler has additive value in a model of "slow onset acute asthma" , namely three AMP provocation tests performed on one day

Inclusion Criteria:

• asthma diagnosis according to ATS criteria,
• lung function (FEV1) above 60% of predicted,
• AMP-PC20 below 160 mg/ml with a documented fall in FEV1 of 30% in this provocation test

Exclusion Criteria:

• having smoked > 10 Pack-years,
• hypersensitivity to one of the study drugs,
• significant co-morbidity, pregnancy or lactating