Treatment Resistant Bipolar Depression

Six Week Double Blind, Randomized Trial of Escitalopram Add On for Treatment Resistant Bipolar Depression

To determine if adding Escitalopram to current mood stabilizer (MS) or atypical antipsychotic (AA) will improve in rates similar to or better than adding a placebo (inactive pill)in resistant bipolar patients.

Inclusion Criteria:

• Age 18 or older
• Diagnosis of Bipolar Disorder and currently be in depressive state, and not responded to mood stabilizer or atypical antipsychotic alone or combined with an antidepressant medication.

Exclusion Criteria:

• Pregnant or breastfeeding
• History of seizure disorder or other unstable medical condition
• Received Electroconvulsive Therapy or Transcranial Magnetic Stimulation in the last three months
• Experienced hallucinations or delusions