This study will compare the efficacy, safety and tolerability of EDP-420 versus another oral antibiotic in the treatment of community acquired pneumonia

Inclusion Criteria:

• Recent respiratory illness with signs and symptoms and chest X-ray consistent with the diagnosis of community-acquired pneumonia.
• Suitable candidate for oral antibiotic therapy and able to swallow large capsules intact
• If female, must be non-lactating and at no risk for pregnancy

Exclusion Criteria:

• Other infections
• Other pulmonary diseases requirement multiple antibacterial medications or long duration of therapy
• History of hypersensitivity, allergic or adverse reactions to macrolide, ketolide, azalide or streptogramins
• Evidence of uncontrolled clinically significant disease, malignancy, or other abnormality
• Requirement of parenteral antimicrobial therapy for treatment of pneumonia
• Currently receiving or likely to receive any known inhibitors or inducers of cytochrome P450 mediated drug metabolism
• Immunocompromised subjects