To determine the safety profile of single and multiple doses of MEDI522 in patients with refractory solid tumors.

Inclusion Criteria:

• Male or post menopausal female patients with histologically confirmed advanced refractory solid tumors for which no reasonable therapy exists. Patient is not required to have measurable disease.
• Age >18 years
• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 (see APPENDIX 1 for details).
• Patients who had prior surgery, radiation, or chemotherapy will be eligible provided at least 4 weeks have elapsed prior to study initiation. Patients must have recovered from treatment-related toxicities, and surgical wounds must be healed.
• Patients who have had prior immunotherapy with approved agents are eligible.
• Patients must have hemoglobin >10.0 g/dL, ANC >1,000/mm3, WBC >3,000/mm3,000/mm3, platelets ³100,000/mm3, bilirubin £2.0 mg/dL, AST/ALT no greater than 5 times the upper limit of normal (ULN), and serum creatinine <1.5 mg/dL (or calculated creatinine clearance ³60 mL/min).
• Patients must have prothrombin time (PT) and partial thromboplatin time (PTT) less than upper limit of normal or international normalized ratio (INR) less than 1.1.
• Patients must have thyroxine (T4) and thyroid-stimulating hormone (TSH) within normal limits.
• Patients must be informed of and understand the investigational nature of this trial and give written informed consent prior to receipt of any study medication or beginning study procedures.

Exclusion Criteria:

• Patient has known brain metastases or primary brain tumors, symptomatic pleural effusion or ascites requiring paracentesis.
• Patient has respiratory insufficiency requiring oxygen treatment, or has lymphangitic involvement of lungs.
• Patient has evidence of hematemesis, melena, hematochezia, or hematuria (2 or greater on urine dipstick).
• Patient has a history of a significant adverse event related to previously administered humanized monoclonal antibody.
• Patient has known HIV or hepatitis virus infection.
• Patient has prior myocardial infarction or angina, or uncontrolled hypertension (systolic BP >140 mm Hg).
• Patient has either prior strokes or transient ischemic attacks.
• Patient has active infections requiring systemic antiinfective therapy or other physical or psychological illnesses that would preclude drug administration or patient compliance.
• Patient has donated blood or received an investigational agent in the last 4 weeks.
• Patient has a history of active illness or behavior, including substance dependence or abuse that, in the opinion of the investigator, might pose additional risk in administering the study drug to the patient.
• General medical or psychological conditions that would not permit the patient to complete the study or sign the informed consent