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| Name | Class |
|---|---|
| Generalkonsul Einar Høyvalds Fond | UNKNOWN |
| Jørgen Bagenkop Nielsens Myopi-Fond | UNKNOWN |
| Chr. Andersen og hustru Ingeborg Andersen, f. Schmidts legat (fond) oprettet af deres datter, frk. Lilli Ellen Andersen. |
7-methylxanthine has been shown to increase the concentration and thickness of collagen fibrils in rabbit sclera. Deficient collagen in the sclera may be the cause of progression of childhood myopia. The study hypothesis is that treatment with 7-methylxanthine will stabilize the sclera and prevent further progression of myopia.
Participants are given tablets of 7-methylxanthine 400 mg per day or placebo tablets for 12 months. Axial length, cycloplegic refraction and corneal curvature is measured, as well as weight, height, blood pressure and heart rate. The participants are interviewed about possible CNS, gastrointestinal, or cardiopulmonal side effects.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 7-methylxanthine | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Axial growth |
| Measure | Description | Time Frame |
|---|---|---|
| Myopia progression |
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Inclusion Criteria:
Children in the age 8-13 years with myopia and an axial growth rate of 0.15 mm or more per year.
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Exclusion Criteria:
Severe general ailment (for example diabetes, epilepsy, psychiatric disease) Eye diseases (for example cataract, keratoconus, chronic iritis, glaucoma)
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| Name | Affiliation | Role |
|---|---|---|
| Klaus Trier, MD | Trier Research Laboratories | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10574816 | Background | Trier K, Olsen EB, Kobayashi T, Ribel-Madsen SM. Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine. Br J Ophthalmol. 1999 Dec;83(12):1370-5. doi: 10.1136/bjo.83.12.1370. | |
| 36809645 | Derived | Lawrenson JG, Shah R, Huntjens B, Downie LE, Virgili G, Dhakal R, Verkicharla PK, Li D, Mavi S, Kernohan A, Li T, Walline JJ. Interventions for myopia control in children: a living systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Feb 16;2(2):CD014758. doi: 10.1002/14651858.CD014758.pub2. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Sep 21, 2009 | |
| Reset | Oct 20, 2009 | |
| Release | Oct 22, 2009 | |
| Reset | Nov 24, 2009 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Sep 21, 2009 | Oct 20, 2009 | |||
| Oct 22, 2009 |
| ID | Term |
|---|---|
| D009216 | Myopia |
| ID | Term |
|---|---|
| D012030 | Refractive Errors |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| C064273 | 7-methylxanthine |
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| 23380471 | Derived | Cui D, Trier K, Munk Ribel-Madsen S. Effect of day length on eye growth, myopia progression, and change of corneal power in myopic children. Ophthalmology. 2013 May;120(5):1074-9. doi: 10.1016/j.ophtha.2012.10.022. Epub 2013 Feb 4. |
| Nov 24, 2009 |