Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation

Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation

Randomisation between postoperative administration of an ACE-inhibitor or not.

Children that are undergoing elective surgery for the creation of a Fontan circulation will be randomised to postoperative administration of an ACE-inhibitor or not.

Determination of aldosteron, renine and ADH in serum preoperatively and 1h, 12h and 5 days postoperatively.

Inclusion Criteria:

• All consecutive children with a univentricular heart disease undergoing elective surgery for creation of a Fontan circulation
• Parents have agreed with the study after informed consent

Exclusion Criteria:

• Urgent / Emergent surgery
• Preoperative use of an ACE-inhibitor