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| ID | Type | Description | Link |
|---|---|---|---|
| ACTR012605000781640 |
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| Name | Class |
|---|---|
| Abbott | INDUSTRY |
| Boehringer Ingelheim | INDUSTRY |
| GlaxoSmithKline | INDUSTRY |
| Bristol-Myers Squibb |
To compare two commercially available platforms for assessment of HIV drug resistance to determine which provides superior virological results.
We hypothesise that one test will be significantly superior to the other.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A: subjects assign to receive a GENOTYPE | Experimental | randomised prior to the selection of their new cART regimen |
|
| Group B: subjects assign to receive a VIRTUAL PHENOTYPE | Experimental | randomised prior to the selection of their new cART regimen |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood test: genotype testing | Diagnostic Test |
|
| Measure | Description | Time Frame |
|---|---|---|
| The comparison between randomly assigned study arms in the mean area under the curve plasma HIV RNA at 48 weeks. | at 48 weeks follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with undetectable plasma HIV RNA, Changes in CD4+ cell count, use of resistance test result in selecting new ART regimen | at 48 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sean Emery, PhD | The National Centre in HIV Epidemiology and Clinical Research at the University of New South Wales | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Interchange General Practice | Canberra | Australian Capital Territory | Australia | |||
| Royal Prince Alfred Hospital |
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| INDUSTRY |
| Merck Sharp & Dohme LLC | INDUSTRY |
| Roche Pharma AG | INDUSTRY |
| Virco | INDUSTRY |
| Diagnostic Technology | INDUSTRY |
| Perkin Elmer Inc. | INDUSTRY |
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| Camperdown |
| New South Wales |
| 2050 |
| Australia |
| Sydney Sexual Health Clinic | Sydney | New South Wales | 2000 | Australia |
| AIDS Research Initiative | Sydney | New South Wales | 2010 | Australia |
| Albion Street Centre | Sydney | New South Wales | 2010 | Australia |
| Holdsworth House General Practice | Sydney | New South Wales | 2010 | Australia |
| St. Vincent's Hospital | Sydney | New South Wales | 2010 | Australia |
| Taylor Square Private Clinic | Sydney | New South Wales | 2010 | Australia |
| Prince of Wales Hospital | Sydney | New South Wales | 2031 | Australia |
| Livingston Road Sexual Health | Sydney | New South Wales | Australia |
| QLD Health - AIDS Medical Unit | Brisbane | Queensland | 4002 | Australia |
| Cairns Base Hospital | Cairns | Queensland | 4870 | Australia |
| Gold Coast Sexual Health Clinic | Miami | Queensland | 4220 | Australia |
| Care and Prevention Programme | Adelaide | South Australia | Australia |
| Alfred Hospital | Melbourne | Victoria | 3004 | Australia |
| Melbourne Sexual Health Centre | Melbourne | Victoria | 3053 | Australia |
| Prahran Market Clinic | Melbourne | Victoria | 3141 | Australia |
| Fremantle Hospital | Fremantle | Western Australia | 6160 | Australia |
| Royal Perth Hospital | Perth | Western Australia | 6000 | Australia |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
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