Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Aichi Gakuin University | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Cardiovascular disease is a complex multifactorial and polygenic disorder that is thought to result from an interaction between a person's genetic make up and various environmental factors. Although many studies have revealed that several genetic variants increase the risk of cardiovascular disease, the results of these studies remain controversial. The purpose of this study is to identify polymorphisms that confer susceptibility to cardiovascular disease and to clarify the adequacy of reported susceptibility gene polymorphisms. To complete this purpose, we will prospectively study over 5,000 local residents in whom relationship between these polymorphisms and occurrence of cardiovascular disease over 5 years.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Inclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mitsuhiro Yokota, MD, PhD | Contact | +81-52-759-2111 | 369 | myokota@dpc.aichi-gakuin.ac.jp |
| Mitsuhiro Yokota, MD, PhD | Contact | +81-52-744-5515 | mitsuhiro.yokota@theranos-inst.com |
| Name | Affiliation | Role |
|---|---|---|
| Mitsuhiro Yokota, MD, PhD | Department of Genome Science, School o Dentistry, Aichi-Gakuin University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Genome Science, School of Dentistry, Aichi-Gakuin University | Recruiting | Nagoya | Aichi-ken | 464-8651 | Japan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41592914 | Derived | Ohashi Y, Ichihara S, Yamamoto K, Kitamura Y, Matsubara T, Beppo R, Kinoshita F, Kato TS, Toyoda Y, Kawamura Y, Matsuo H, Ichida K, Yokota M, Nakatochi M. Proteomic footprint of serum urate concentration and urate transporter ABCG2 dysfunctional polymorphism: a cross-sectional study. RMD Open. 2026 Jan 27;12(1):e006414. doi: 10.1136/rmdopen-2025-006414. | |
| 28515798 |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D009203 | Myocardial Infarction |
| D002544 | Cerebral Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M. Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. Clin Epigenetics. 2017 May 15;9:54. doi: 10.1186/s13148-017-0353-3. eCollection 2017. |
| 21458098 | Derived | Nakatochi M, Miyata S, Tanimura D, Izawa H, Asano H, Murase Y, Kato R, Ichihara S, Naruse K, Matsubara T, Honda H, Yokota M. The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population: results from the KING Study. Diabetes Res Clin Pract. 2011 Jun;92(3):e61-5. doi: 10.1016/j.diabres.2011.02.029. Epub 2011 Mar 31. |
| 21150884 | Derived | Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet. 2011 Mar;19(3):262-9. doi: 10.1038/ejhg.2010.201. Epub 2010 Dec 8. |
| 19727657 | Derived | Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, Shintani S, Nishizawa T, Tanimura D, Naruse K, Matsubara T, Murohara T, Yokota M. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. Diabetologia. 2010 Feb;53(2):234-46. doi: 10.1007/s00125-009-1517-2. Epub 2009 Sep 1. |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D020520 | Brain Infarction |
| D002545 | Brain Ischemia |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020521 | Stroke |