Treatment of Orthostatic Intolerance

Treatment of Orthostatic Intolerance

This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.

This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.

Pilot drug trials are 4h in duration from ~9am -1pm. Different short-acting medications will be used to determine their acute hemodynamic effects in patients with orthostatic intolerance.

Inclusion Criteria:

• Chronic symptoms (> 6 months) with standing upright

Exclusion Criteria:

• Obvious cause of hypovolemia or drugs that could worsen tachycardia
• Chronic severe medical conditions such as cancer or ischemic heart disease