This five-year prevention services application is concerned with preventing substance abuse, comorbid mental and behavioral disorders, and school failure. We will direct an integrated set of first grade classroom based preventive interventions at two correlated and confirmed early antecedents: early aggressive, disruptive behavior and poor achievement. We will test a comprehensive Whole Day (WD) program directed at improving: 1) teacher's classroom behavior management; 2) family/classroom partnerships regarding homework and discipline; and 3) teacher's instructional practices regarding academic subjects, particularly reading. We will test WD effectiveness in a developmental epidemiological design in which children and teachers are randomly assigned to intervention and standard setting (control) classrooms in 2 classrooms in each of 12 schools. While following the first grade children to the end of third grade, we will follow their first grade teachers over two subsequent cohorts of first graders to test whether the support and training structure sustains high levels of WD practice. We will also test whether the support and training structure is successful in training non-WD teachers. This prevention services aim will be augmented by an economic analysis of the costs and cost-effectiveness of the WD program. This combined services and prevention research should increase the efficiency of developing evidence-based programs and extending their use system-wide in both the prevention and education fields. The aims of our proposed work are to: 1) Implement and evaluate the effectiveness of a whole-day preventive intervention program for first-grade (WD) directed at known antecedent risk factors for later substance abuse, school failure, and comorbid mental and behavioral disorders; 2) Measure the variation in impact of WD due to variation in the experimentally manipulated quality of teachers' specific WD practices around classroom behavior management, family/classroom partnership, and quality of instruction, regarding reading, taking into account family, peer, and community factors; 3) Test effective- ness of the support structure required to sustain, and extend to other teachers high quality implementa- tion of WD; 4) Carry out economic analyses of the costs of implementing WD and their cost-effectiveness.

This five-year application is concerned with preventing substance abuse, comorbid mental and behavioral disorders, and school failure. We will direct an integrated set of previously tested preventive first-grade interventions at two correlated and confirmed early antecedents: early aggressive, disruptive behavior and poor achievement. The interventions we propose to integrate and test are directed at improving: 1) teacher's classroom behavior management; 2) family/classroom partnerships regarding homework and discipline; and 3) teacher's instructional practices regarding academic subjects, particularly reading. The combined preventive and educational intervention strategy will be a single Whole Day (WD) first-grade classroom program, built on the empirically determined recognition of the interdependence of these risk factors across substance abuse and educational failure. As in our past Baltimore preventive trials, we propose to test the effectiveness of WD in a developmental epidemiological design in which children and teachers are randomly assigned to intervention and standard setting conditions (controls; SC). A special aspect of this proposal is that in the same design we propose laying a foundation for moving what we have learned into policy and practice. While following the first-grade children as far as the end of third grade, we will follow their first grade teachers over two subsequent cohorts of first graders, to test whether the support and training structure sustains high levels of WD practice. We will also test whether the support and training structure is successful in training non-WD teachers, as far as the trial results warrant. This prevention services aim will be augmented by an economic analysis of the costs and effectiveness of the WD program. The research on effectiveness combined with research on moving from effectiveness to practice should increase the efficiency of developing evidence-based programs faster and earlier in both the prevention and education fields.

This grant would set the foundation for grants for following the cohort of study children and teachers periodically to assess the preventive impact of the interventions on later substance abuse and on extending teachers' use of WD practices. This prevention research in Baltimore continues under the aegis of our Community and Institutional Board (see letters of support). This proposal involves a close institutional collaboration among the American Institutes for Research (AIR); Baltimore City Public School System (BCPSS); Morgan State University (MSU); the Oregon Social Learning Center (OSLC); the Prevention Science and Methodology Group (PSMG); the Johns Hopkins Bloomberg School of Public Health; and the Center for Academic and Reading Skills at the University of Texas-Houston.

The aims of our proposed work are to

1. Implement and evaluate the effectiveness of a whole-day preventive intervention program for first grade (WD) directed at reducing the antecedent risk factors for later substance abuse, comorbid mental and behavioral disorders, and school failure.
2. Measure the variation in the impact of WD owing to variation in the experimentally manipulated quality of teachers' specific WD practices around classroom behavior management, family/classroom partnership, and quality of instruction, particularly regarding reading. These analyses will include other sources of variation as well, in the child and in the social contexts of family, classroom and school, peers, and community.
3. Test the effectiveness of the support and training structure required to develop and maintain high-quality implementation of WD a) during the effectiveness trial; then b) as the results warrant, sustaining high-quality WD in consecutive cohorts of first graders; and then c) extending the hypothesized higher quality of WD to other than WD teachers.
4. Carry out economic analyses of the costs of implementing WD and their cost-effectiveness compared with SC with respect to reductions in risk factors for illicit substance abuse, as well as tobacco, HIV, school failure, and comorbid mental and behavioral disorders.

B. Background and Significance Over the past three decades, evidence from developmental epidemiological studies has consistently identified specific antecedent risk factors at least as early as first grade as predictive of later substance abuse and comorbid mental and behavioral disorders during the middle school years and beyond (Cairns, Cairns, & Neckerman, 1995; Farrington, 1995; Hawkins, Catalano, & Miller, 1992; Hawkins, Doueck, & Lishner, 1988; Kellam, Brown, Rubin, & Ensminger, 1983; Reid, 1993; Reid & Eddy, 1997). Many of these antecedents are exhibited in the school setting, such as aggressive, disruptive behavior in first grade and its strong correlate, poor academic achievement. These early risk factors can lead to later substance abuse and school dropout, which have considerable economic, social, and psychological consequences (Dishion, Capaldi, & Yoerger, 1999; Eddy, Reid, & Fetrow, 2000; Hawkins et al., 1992; Kellam et al., 1983; Kellam, Mayer, Rebok, & Hawkins, 1998; Maguin & Loeber, 1996; Mrazek & Haggerty, 1994; Reid, Eddy, Fetrow, & Stoolmiller, 1999 [see Appendix-1 for paper]). These risk factors are also strongly related to a host of other risk factors that separately or together are predictive during adolescence and young adulthood of not only drug abuse, but also conduct disorders and violence, depression, school drop out, and high-risk sexual behaviors. Ineffective parenting around discipline and homework; classrooms with high levels of aggressive, disruptive behavior; antisocial classmates and peers; poverty at the family level and at the school and community levels, and individual differences such as sensation seeking (Wills, Sandy, & Yaeger, 2000; Palmgreen, Donohew, Lorch, Hoyle, & Stephenson, 2001)-all have been found to increase the risk of drug abuse and related comorbid problems (Ary et al., 1999; Dishion et al., 1999; Kellam, Ling, Meriska, Brown, & Ialongo, 1998 [see Appendix-2 for paper]; Reid, Patterson, & Snyder, in press).

In Baltimore, in Oregon, and elsewhere, rigorous, developmental, epidemiologically based, randomized field trials have directed interventions at decreasing the early risk factors in the classroom, family, and peer-group settings. These trials indicate that school-based universal interventions (i.e., those addressing all children, not merely those at higher risk) can have short-term beneficial effects on aggressive behavior and achievement (Dolan et al., 1993; Ialongo et al., 1999; Reid, et al., 1999), off-task behavior (Brown, 1994a, 1993b), and depressive symptoms (Kellam, Rebok, Mayer, Ialongo, & Kalodner, 1994). Impact from first grade interventions to reduced aggression in middle school has been reported (Kellam, Rebok, Ialongo, & Mayer [see Appendix-3 for paper], 1994; Kellam, Ling et al., 1998), and delinquency (Eddy et al., 2000). Longer-term effects on illicit drug use have been observed in the Baltimore work (see Figure 1). Reductions in the initiation of tobacco use have been shown as a result of the Baltimore first grade preventive interventions in three separate cohorts (Kellam & Anthony, 1998 [see Appendix-4 for paper]; Storr, Ialongo, Kellam, & Anthony, in press). Longer-term impact has been reported in meta-analyses on illicit drug use by Nan Tobler and colleagues (1986; 2000; Tobler et al., 2000) plus other meta-analyses (Derzon & Lipsey, 1999; Gorman, 1995). Higher-fidelity implementation of the interventions also led to higher impact (Ialongo et al., 1999 [see Appendix-5 for paper], Ialongo, Poduska, Werthamer, & Kellam, 2001 [see Appendix-6 for paper]). Further, we have found compelling evidence that these universal interventions often have the greatest impact on those at highest risk of substance abuse and aggression (Brown & Liao, 1999 [see Appendix-7 for paper]; Curran & Muthèn, 1999; Muthèn & Curran, 1997; Muthèn et al., submitted; Stoolmiller, Eddy, & Reid, 2000 [see Appendix-8 for paper]).

Inclusion Criteria:

Must be a first grade child in regular first grade classrooms in 12 schools in 2 academic areas of Baltimore City Public School System

Exclusion Criteria:

• None