Sopran - Omeprazole Treatment Versus Surgery

Omeprazole Versus Anti-reflux Surgery in the Long-term Management of Peptic Esophagitis - a 10 Year Follow up Study of Patients Previously Studied for 5 Years - A Nordic Multicentre Study

The purpose of this study is to study gastritis, GI symptoms during long term omeprazole treatment

Inclusion Criteria:

• Previous inclusion into Astra study I-635 and willing to continue for another 10 years,

Exclusion Criteria:

• Pregnancy or lactation; Woman planning pregnancy within 5 years; Suspected or confirmed malignancy; Documented eradication of Helicobacter pylori.