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| ID | Type | Description | Link |
|---|---|---|---|
| OTT 02-04 | Other Identifier | OHRI | |
| CERHO 2002263-01H | Other Identifier | OHRI |
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| Name | Class |
|---|---|
| Canadian Cancer Trials Group | NETWORK |
Androgen Deprivation Therapy is a commonly used treatment for men with Prostate Cancer. Unfortunately this can lead to functional decline, fatigue, increased body fatness, loss of lean body tissue and impaired QOL. Previous research has demonstrated the exercise can may reduce fatigue and improve QOL in men on ADT. This study will evaluate whether aerobic versus resistance exercise over a 24 week period of training will reduce morbidity and improve QOL in men receiving radiation plus or minus ADT with curative intent
A total of 220 men with a diagnosis of prostate cancer, scheduled to receive radiation will be recruited. The study is a parallel 3-group design with groups stratified for intended duration of ADT ( greater or less than 12 weeks) and random assignment to aerobic, resistance or Wait List control groups. The dependent variable of interest will fatigue measured at 24 weeks by the 13 item FACT-Fatigue. Dependent variables of secondary interest will be toxicity of radiation, body composition, muscular fitness, cardio-respiratory fitness, metabolic fitness, and prostate specific QOL. All exercise sessions will be performed 3 times per week at the Ottawa Hospital regional Cancer Center
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Arm | No Intervention | No exercise measured | |
| Aerobic cardiovascular exercise program | Experimental | Aerobic cardiovascular exercise program |
|
| Resistance Exercise Program | Experimental | Resistance Exercise Program |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic cardiovascular exercise program | Behavioral | Aerobic cardiovascular exercise program |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fatigue- FACT F | 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Toxicity of Radiotherapy Body Composition Muscular Fitness Cardiorespiratory Fitness Metabolic Fitness Prostate Specific QOL | 24 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Roanne Segal | OHRI | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Ottawa Hospital-Integrated Cancer Program | Ottawa | Ontario | K1H-1C4 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12721238 | Result | Segal RJ, Reid RD, Courneya KS, Malone SC, Parliament MB, Scott CG, Venner PM, Quinney HA, Jones LW, D'Angelo ME, Wells GA. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol. 2003 May 1;21(9):1653-9. doi: 10.1200/JCO.2003.09.534. |
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| ID | Term |
|---|---|
| D011471 | Prostatic Neoplasms |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Resistance Exercise Program | Behavioral | Resistance Exercise Program |
|
| D005832 |
| Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |