Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients

Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis (FAP) Patients

The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form of colorectal cancer.

Inclusion Criteria:

• Familial adenomatous polyposis
• 18 years of age or older
• 5 or more adenomas of colorectum or ileum

Exclusion Criteria:

• Female patient of child bearing age not on effective birth control pills
• Pregnant women
• White blood cell (WBC) count less than 4000
• Platelets (Plts) less than 100,000
• Blood urea nitrogen (BUN) greater than 25
• Creatine greater than 1.5
• Patients unable to stop non-steroidal anti-inflammatory drugs (NSAIDs) during duration of trial
• Malignancy
• Patient with active bacterial infections of gastroesophageal reflux disease or peptic ulcer disease
• Patient on warfarin or anti-platelet drugs