Comparison Study of Letrozole Alone or Letrozole With Zoledronic Acid in Early Breast Cancer, Neoadjuvant Therapy

Randomized Multi-Center Study Comparing Prolonged Primary Systemic Endocrine Therapy With Letrozole Alone or in Combination With Zoledronic Acid in Early Breast Cancer (NEOadjuvant Study in CANada)

This study is to measure the extent of tumor shrinkage when Letrozole and Zoledronic Acid are given before surgery to newly diagnosed post-menopausal women with early breast cancer

Inclusion Criteria

• Postmenopausal women
• Newly diagnosed with non metastatic breast cancer
• Candidate for mastectomy or breast-conserving surgery

Exclusion Criteria

• Patients with invasive tumors
• Patients receiving anti-cancer treatment
• Patients who have undergone surgery

Other protocol-defined exclusion criteria may apply.