Strict Glucose Control of Pediatric Intensive Care Unit (ICU) Patients

Strict Glucose Control of Pediatric ICU Patients to Reduce Mortality and Morbidity

The study objective is to improve morbidity and mortality of high-risk critically ill children. Our hypothesis is that a strict ICU glucose control protocol will decrease morbidity and mortality associated with hyperglycemia in a population of high-risk critically ill pediatric patients.

Inclusion Criteria:

• Vasoactive infusion (e.g. dopamine, epinephrine, norepinephrine) and/or
• Invasive mechanical ventilation
• Age between 1 mo and 21 yrs

Exclusion Criteria:

• Type I diabetes mellitus
• Have an illness that requires insulin daily
• Recipients of solid organ transplants
• Participation in an experimental trial that might affect outcome
• Post-operative patients with planned extubation upon recovery
• Patients on a dopamine infusion of less than 3 mcg/kg/minute