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The aim of the study is to compare the clinical efficacy of three types of plasma secured on the viral level either by quarantine or by chemical treatment in patients undergoing liver transplantation.
Three types of plasma are transfused in bleeding patients undergoing liver transplantation:
In addition, the correction of coagulation abnormalities are studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Quarantined FFP | Active Comparator | Quarantined FFP |
|
| Methylene blue FFP | Active Comparator | Methylene blue FFP |
|
| Solvent detergent FFP | Active Comparator | Solvent detergent FFP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| plasma | Other | transfusion of more than 15 mL/Kg of plasma |
|
| Measure | Description | Time Frame |
|---|---|---|
| Volume of transfused plasma during surgery | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| correction of coagulation abnormalities | 5 years | |
| immediate and delayed adverse events | 15 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yves Ozier, MD, PhD | Hôpital Cochin, Paris, France | Principal Investigator |
| Emmanuel Samain, MD, PhD | hôpital Jean Minjoz, Besançon, France | Principal Investigator |
| Marie - Christine Gillon, MD | Hôpital Paul Brousse, Villejuif, France | Principal Investigator |
| Loïc Villalon, MD | Hôpital Pontchaillou | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| EFS | Paris | 75015 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22998014 | Derived | Bartelmaos T, Chabanel A, Leger J, Villalon L, Gillon MC, Rouget C, Gomola A, Denninger MH, Tardivel R, Naegelen C, Courtois F, Bardiaux L, Giraudeau B, Ozier Y. Plasma transfusion in liver transplantation: a randomized, double-blind, multicenter clinical comparison of three virally secured plasmas. Transfusion. 2013 Jun;53(6):1335-45. doi: 10.1111/j.1537-2995.2012.03895.x. Epub 2012 Sep 24. |
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| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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