Plasma Transfusion in Liver Transplantation

Plasma Transfusion in Liver Transplantation : a Randomized, Double Blind, Multicenter Trial of Methylene Blue, Solvent/Detergent and Quarantined Plasma.

The aim of the study is to compare the clinical efficacy of three types of plasma secured on the viral level either by quarantine or by chemical treatment in patients undergoing liver transplantation.

Three types of plasma are transfused in bleeding patients undergoing liver transplantation:

• quarantined plasma,
• methylene blue treated plasma,
• solvent/detergent plasma. The main purpose is to show that the volume of methylene blue treated plasma consumed intraoperatively is equivalent to that of the 2 other types of plasma.

In addition, the correction of coagulation abnormalities are studied.

Inclusion Criteria:

• age 18 yo and above
• consent is signed,
• liver transplantation is indicated,
• plasma is transfused

Exclusion Criteria:

• multiorgan transplantation (except combined kidney and liver transplantation)
• allergy to methylene blue.