Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux

Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux

This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.

This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.

Inclusion Criteria:

Main inclusion criteria :

• Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).
• Need of upper GI endoscopy and pH monitoring.
• Normal propagation of oesophageal persitaltic waves (manometry < 6 months).
• Age 18 -70 yrs
• Signed informed consent
• Normal coagulation

Exclusion Criteria:

• Barrett's oesophagus
• Previous oesophageal bleeding
• Need of NSAID treatment.
• Previous sus mesocolic surgery
• Alcool consumption > 40g/d, smoking > 10 cig/j
• Pregnancy or lack of contraceptive disposal, breast feeding.
• Allergy to Xylocaïne