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| Name | Class |
|---|---|
| Mukoviszidose eV (German CF society) | UNKNOWN |
| Schweizer CF-Gesellschaft (Swiss CF society) | UNKNOWN |
| Hannover Medical School | OTHER |
| Goethe University |
The purpose of this randomized, controlled trial was to determine whether a (and if so which) physical conditioning program is effective to improve health status, physical activity, and quality of life in patients with cystic fibrosis. A positive effect of physical conditioning was expected.
A high level of physical activity might be beneficial for patients with cystic fibrosis (CF). Several studies have indicated that physical training might improve fitness and lung functions (or, at least, slow the decline in lung functions). However, there are no long-term studies comparing the effects among aerobic training, strength training and no training. Furthermore, motivation to continue a training with little variations between sessions has been shown to decline rapidly. Thus, adherence with such a program may be low. Finally, not all patients feel happy with the same program. Therefore, a home-based individualized sports program might be best suitable to achieve long term benefits. The MUKOTRAIN study is a multicenter randomized controlled trial to determine the effects of a home-based physical training in patients with CF.
Comparisons:
Study A) Patients training aerobically 3 * 30 min per week (supervised in a sports club near their homes) in addition to their baseline physical activity compared to patients training upper and lower body strength 3 * 30 min per week (supervised in a sports club near their homes) compared to patients maintaining their physical activity. The supervised intervention lasted 6 months, thereafter patients were followed for an additional 18 months.
Study B) Patients asked to participate in sport activities at least 3 * 60 min per week (free choice of activities) in addition to their baseline physical activity compared with patients asked to maintain their baseline physical activity.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Supervised aerobic training | Behavioral | |||
| Supervised strength training | Behavioral | |||
| Unsupervised training | Behavioral |
| Measure | Description | Time Frame |
|---|---|---|
| Change in lung functions determined at 0,3,6,12,18,24 months | ||
| Change in exercise capacity determined at 0,3,6,12,18,24 | ||
| months | ||
| Change in physical activity determined at 0,3,6,12,18,24 months | ||
| Change in quality of life determined at 0,3,6,12,18,24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in body fatness at 0,3,6,12,18,24 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Helge U Hebestreit, MD | Julius-Maximilians University, Würzburg, Germany | Principal Investigator |
| Susi Kriemler, MD | Stadtspital Triemli, Zürich Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johann Wolfgang Goethe Universität | Frankfurt | 60590 | Germany | |||
| Medizinische Hochschule |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24571729 | Derived | Hebestreit H, Schmid K, Kieser S, Junge S, Ballmann M, Roth K, Hebestreit A, Schenk T, Schindler C, Posselt HG, Kriemler S. Quality of life is associated with physical activity and fitness in cystic fibrosis. BMC Pulm Med. 2014 Feb 27;14:26. doi: 10.1186/1471-2466-14-26. | |
| 23588193 | Derived | Kriemler S, Kieser S, Junge S, Ballmann M, Hebestreit A, Schindler C, Stussi C, Hebestreit H. Effect of supervised training on FEV1 in cystic fibrosis: a randomised controlled trial. J Cyst Fibros. 2013 Dec;12(6):714-20. doi: 10.1016/j.jcf.2013.03.003. Epub 2013 Apr 13. |
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| OTHER |
| Triemli Hospital | OTHER |
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| Hanover |
| 30625 |
| Germany |
| Children´s Hospital, Julius Maximilians University | Würzburg | 97080 | Germany |
| Stadtspital Triemli | Zurich | 8057 | Switzerland |
| 19643946 | Derived | Hebestreit H, Kieser S, Junge S, Ballmann M, Hebestreit A, Schindler C, Schenk T, Posselt HG, Kriemler S. Long-term effects of a partially supervised conditioning programme in cystic fibrosis. Eur Respir J. 2010 Mar;35(3):578-83. doi: 10.1183/09031936.00062409. Epub 2009 Jul 30. |
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
| D001519 | Behavior |