Safety, Efficacy, Dose-finding Study of a Monoclonal Antibody in Patients With Multiple Myeloma

A Phase I, Dose-finding Trial of HCD122, an Anti-CD40 Monoclonal Antibody, in Patients With Multiple Myeloma That is Relapsed or Has Not Responded to Prior Therapy (CHIR1212-C12101)

The purpose of this study is to determine the highest tolerated dose, safety and activity of HCD122 in patients with Multiple Myeloma who are relapsed after receiving prior treatment.

Inclusion Criteria:

• Clinical Diagnosis of MM requiring treatment
• Refractory or Relapsed Disease
• At least one prior treatment regimen
• Male or Female
• >18 years of age

Exclusion Criteria:

• Prior Allogeneic bone marrow transplant (prior autologous transplant allowed)
• Intracranial disease or epidural disease
• Clinically significant cardiac dysfunction or other significant organ dysfunction