Cognitive Effects of Immunomodulatory Drugs in MS

Comparison of the Cognitive Effects of Three Immunomodulatory Drugs in Relapsing-Remitting Multiple Sclerosis: A Longitudinal Study

The purpose of this study is to examine and compare changes in the specific thinking skills of patients with RRMS who are receiving treatment with one of three immunomodulatory medications (Avonex, Copaxone, or Rebif).

In addition this study will compare the patients' personal view of how they are doing, any changes in physical disability, and the frequency and severity of relapses over the three year period.

Inclusion Criteria:

• Diagnosis of RRMS for at least one year,
• Currently on one of three immunomodulatory drugs (Avonex, Copaxone, or Rebif),
• Visual Acuity is 20/50 or better,
• patient has four color vision,
• Must have at least a high school education

Exclusion Criteria:

• History of head injury, drug/alcohol abuse, and/or psychiatric problems, -current diagnosis of a severe or lifethreatening disease other than MS,
• currently taking immunosuppressant medication,
• resides greater than 200 miles from the study site