Effect of APC and Epo on the Inflammatory Response During Sepsis

Effect of Activated Protein C and Erythropoietin on the Microvascular Inflammatory Response During Severe Sepsis.

An observational study to determine the effect of APC and Epo in reducing the systemic inflammatory response during severe sepsis.

An observational study to determine the effect of APC and Epo in reducing the systemic inflammatory response during severe sepsis. Patients already prescribed either drug will be enrolled. The microcirculation of the sublingual vascular bed will be observed with a microscope to detect the alterations in the inflammatory response.

Inclusion Criteria:

• patients in the ICU in severe septic shock undergoing APC and/or Epo treatment

Exclusion Criteria:

• any severe comorbid conditions