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| Name | Class |
|---|---|
| Numico Research Wageningen, the Netherlands | UNKNOWN |
To study the effect of supplementation of a hydrolyzed formula with probiotic bacteria on clinical and immunological parameters in infants with AD with and without CMA and to compare effectiveness of different strains of probiotics.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| probiotics: Lactobacillus GG, lactobacillus Rhamnosus | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Significant decrease of SCORAD score in treated infants compared to placebo |
| Measure | Description | Time Frame |
|---|---|---|
| IL-4, IL-5 and IFN-gamma production of stimulated peripheral blood mononuclear cells | ||
| change in fecal TNF-α and α-1-antitrypsin, urinary EDN | ||
| effect on faecal bacteria after probiotics |
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Inclusion Criteria:
Term infants fulfilling the Hanifin (1989) criteria for atopic dermatitis
Exclusion Criteria:
• Previous or current use of anti-histamines, oral corticosteroids, probiotics
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| Name | Affiliation | Role |
|---|---|---|
| Eric J Duiverman, MD, PhD | Dept of Pediatric Pulmonology, University Medical Center Groningen, The Netherlands | Principal Investigator |
| Marianne L Brouwer, MD | Dept of Pediatric Pulmonology, University Medical Center Groningen, The Netherlands | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beatrix Children's Hospital, University Medical Center Groningen | Groningen | 9700 RB | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16839405 | Result | Brouwer ML, Wolt-Plompen SA, Dubois AE, van der Heide S, Jansen DF, Hoijer MA, Kauffman HF, Duiverman EJ. No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial. Clin Exp Allergy. 2006 Jul;36(7):899-906. doi: 10.1111/j.1365-2222.2006.02513.x. |
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| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
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