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| Name | Class |
|---|---|
| Massachusetts General Hospital | OTHER |
This study compares the effects of 12 weeks of treatment with transdermal versus oral estrogen therapy on testsoterone levels and thyroid tests in healthy, naturally menopausal women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sequence A | Experimental | Oral ERT then transdermal ERT |
|
| Sequence B | Experimental | Transdermal ERT then oral ERT |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Premarin® (oral) vs. Alora® (transdermal) | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Compare the effects of a 12-week course of oral CEE to a 12-week course of transdermal estradiol on free testosterone concentrations in menopausal women. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the effects of oral versus transdermal ERT on thyroid binding globulin concentrations and tests of thyroid function. | 12 weeks | |
| Compare the effects of oral versus transdermal ERT on cortisol binding globulin and total and free cortisol concentrations. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan L Shifren, MD | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
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| ID | Term |
|---|---|
| D004966 | Estrogens, Conjugated (USP) |
| D000279 | Administration, Cutaneous |
| ID | Term |
|---|---|
| D045166 | Estradiol Congeners |
| D012739 | Gonadal Steroid Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
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| 12 weeks |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D000287 | Administration, Topical |
| D004333 | Drug Administration Routes |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |