Cranoc Lipid Study in Renal Transplantation

Cardiovascular Events in Renal Transplant Recipients With Low LDL-cholesterol Receiving Tacrolimus in Combination With the Statin Fluvastatin

Cardiovascular disease after renal transplantation is an important problem. Patients after renal transplantation with low LDL-Levels (<130mg/dl) receive Fluvastatin 80mg/day (or no medication, to look for the cardiovascular outcome with and without statins.

Cardiovascular disease after renal transplantation is an important problem. Patients after renal transplantation with low LDL-Levels (<130mg/dl) receive Fluvastatin 80mg/day (or no medication, to look for the cardiovascular outcome with and without statins.

Inclusion Criteria:

• patients (18 - 65, inclusive)
• cadaver and living kidney transplantation (1. Ntx, 2. Ntx)
• LDL-cholesterol ≤ 130mg/dl (-3 Mo until start of Tx)
• Patients with a history of Myocard infarct: LDL-Cholesterol ≤ 110mg/dl
• Immunsuppression: Tacrolimus in combination with steroids or Mycophenolat Mofetil
• patients indulgence

Exclusion Criteria:

• statin before the study

  • LDL-Cholesterol >130mg/dl before transplantation
  • Instabil Angina, Myocard infarct <6 months before transplantation
  • symptomatic Hypothyreosis
  • child bearing, lactating
  • elavated liver encymes (> 2x elavated: AST, ALT, bilirubine, PCK)
  • Fibrates are not allowed
  • multiorgantransplantation