Viral and Host Factors in the Transmission and Pathogenesis of HIV

Viral and Host Factors in the Transmission and Pathogenesis of HIV

To study the collection of blood from individuals known to be at high risk for HIV-infection or who have been recently infected with HIV.

The data collected are used for diagnostic, prognostic and management decisions as outlined by current HIV-1 Treatment Guidelines.

This phlebotomy protocol permits the collection of blood from individuals known to be at high risk for HIV-infection or who have been recently infected with HIV.

Participants will have from 10 to 60 ml (approximately 1 to 4 tablespoons) of blood drawn for one or all of the following tests:

• T cell subset enumeration
• Serologic reactivity with HIV antigens
• Viral load assays by bDNA, PCR, or RT-PCR
• Routine Laboratory assessments (chemistries, liver function tests, hepatitis serology, RPR)
• HIV-1 Resistance Testing

These data are used for diagnostic, prognostic and management decisions as outlined by current HIV-1 Treatment Guidelines

Inclusion Criteria:

recently infected with HIV-1 HIV-1 negative, and at high risk for infection

Exclusion Criteria:

none