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to compare efficacy and safety of Xalacom with the combination of unfixed Latanoprost and Timolol in subjects with open-angel glaucoma or ocular hypertension
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Xalacom | Drug | |||
| unfixed Latanoprost and Timolol | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| To demonstrate that Xalacom is as effective as uFC latanoprost and timolol at reducing IOP in subjects with open-angel glaucoma or ocular hypertension |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the proportion of subjects reaching specified IOP levels at Week 8 To evaluate the ocular and systemic AEs across all clinic visits |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer Investigational Site | Beijing | Beijing Municipality | 100034 | China | ||
| Pfizer Investigational Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21851642 | Derived | Zhao JL, Ge J, Li XX, Li YM, Sheng YH, Sun NX, Sun XH, Yao K, Zhong Z; Xalacom Study Group in China. Comparative efficacy and safety of the fixed versus unfixed combination of latanoprost and timolol in Chinese patients with open-angle glaucoma or ocular hypertension. BMC Ophthalmol. 2011 Aug 19;11:23. doi: 10.1186/1471-2415-11-23. |
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| Beijing |
| Beijing Municipality |
| 100730 |
| China |
| Pfizer Investigational Site | Guangzhou | Guangdong | 510060 | China |
| Pfizer Investigational Site | Shanghai | Shanghai Municipality | 200092 | China |
| Pfizer Investigational Site | Xi’an | Shanxi | 710004 | China |
| Pfizer Investigational Site | Hangzhou | Zhejiang | 310003 | China |
| Pfizer Investigational Site | Hangzhou | Zhejiang | 310009 | China |
| Pfizer Investigational Site | Shanghai | 200031 | China |
| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| D009798 | Ocular Hypertension |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| C571753 | Xalacom |
| D013999 | Timolol |
| ID | Term |
|---|---|
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D013830 | Thiadiazoles |
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D009025 | Morpholines |
| D010078 | Oxazines |
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