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To evaluate the efficacy and safety of aliskiren alone and in combination with valsartan given to patients with essential hypertension
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| aliskiren | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in diastolic blood pressure after week 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in systolic blood pressure after week 8 | ||
| Diastolic blood pressure < 90 mmHg or a reduction of > 10 mmHg after 4 and 8 weeks | ||
| Blood pressure control target of < 140/90 mmHg after 4 and 8 weeks |
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Inclusion Criteria
Exclusion Criteria
Other protocol-defined exclusion criteria may apply.
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| Name | Affiliation | Role |
|---|---|---|
| Novartis Pharmaceuticals | Novartis Pharmaceuticals | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Novartis Pharmaceuticals | East Hanover | New Jersey | 07936 | United States | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40013543 | Derived | Wang GM, Li LJ, Fan L, Xu M, Tang WL, Wright JM. Renin inhibitors versus angiotensin receptor blockers for primary hypertension. Cochrane Database Syst Rev. 2025 Feb 27;2(2):CD012570. doi: 10.1002/14651858.CD012570.pub2. | |
| 17658393 | Derived | Oparil S, Yarows SA, Patel S, Fang H, Zhang J, Satlin A. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet. 2007 Jul 21;370(9583):221-229. doi: 10.1016/S0140-6736(07)61124-6. |
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| Evaluate 24-hour ambulatory blood pressure monitoring in a subset of patients |
| Investigative Centers |
| Germany |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C446481 | aliskiren |
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