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| Name | Class |
|---|---|
| Rudolf Magnus Institute - University of Utrecht | OTHER |
| Technical University of Twente | OTHER |
| VU University of Amsterdam | OTHER |
| Dept. of Clinical Neurophysiology - VU University Hospital Amsterdam |
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In order to be able to study the effects of evoked fields with magnetoencephalography (MEG) in two groups of patients, comparison is made with a group of healthy volunteers.
This study is directed at the (central and / or peripheral) mechanisms of pain and the cortical changes (plasticity) due to chronic non-malignant pain in two groups of patients and one healthy volunteer group.
The aim of the study is further to evaluate cortical processes by MEG (and fMRI, if feasible) to quantify and qualify the responses, localise the generators and study the effects of a pain therapy.
To search for patterns that may result in diagnostic criteria and have an indicative value for the treatment and the monitoring of the effects.
Finally the study not only intends to support clinical diagnosis but also to provide tools to monitor treatment and support the choice (algorithm) between SCS and SAN. An algorithm, facilitating decision making between these two treatments, will be promoted. It should also provide a clinical decision tool for the use of SAN
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pain study Netherlands | 20 healthy subjects 20 patients with a traumatic unilateral peripheral nerve injury 20 patients with CRPS I |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Evoked fields before and after a local block (Xylocaine) | Other | MEG registration after electrical median and ulnar nerve stimulation in subjects and patients. In the patient group another MEG was performed after an anaesthetic block (1-2 ml Lidocaine 1%) at the site of the nerve injury producing a painfree state |
Inclusion Criteria:
CRPS I:
CRPS II:
Exclusion Criteria:
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subjetcs were sampled from the hospital staff of two hospitals all patients were recruited from one hospital
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| Name | Affiliation | Role |
|---|---|---|
| Peter J Theuvenet, MD | Medical Center Alkmaar | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Center of Alkmaar | Alkmaar | North Holland | 1815 JD | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10449261 | Background | Theuvenet PJ, Dunajski Z, Peters MJ, van Ree JM. Responses to median and tibial nerve stimulation in patients with chronic neuropathic pain. Brain Topogr. 1999 Summer;11(4):305-13. doi: 10.1023/a:1022210704505. | |
| 16040256 | Result | Theuvenet PJ, van Dijk BW, Peters MJ, van Ree JM, Lopes da Silva FL, Chen AC. Whole-head MEG analysis of cortical spatial organization from unilateral stimulation of median nerve in both hands: no complete hemispheric homology. Neuroimage. 2005 Nov 1;28(2):314-25. doi: 10.1016/j.neuroimage.2005.06.010. Epub 2005 Jul 22. |
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| ID | Term |
|---|---|
| D020918 | Complex Regional Pain Syndromes |
| D010146 | Pain |
| D002422 | Causalgia |
| D009437 | Neuralgia |
| ID | Term |
|---|---|
| D001342 | Autonomic Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| OTHER |
| Human Brain Mapping and Cortical Imaging Laboratory, Centre for Sensory - Motor Interaction, | UNKNOWN |
| Aalborg University | OTHER |
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| 16977490 | Result | Theuvenet PJ, van Dijk BW, Peters MJ, van Ree JM, Lopes da Silva FL, Chen AC. Cortical characterization and inter-dipole distance between unilateral median versus ulnar nerve stimulation of both hands in MEG. Brain Topogr. 2006 Winter;19(1-2):29-42. doi: 10.1007/s10548-006-0010-1. |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Aniline Compounds |
| D000588 | Amines |