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| ID | Type | Description | Link |
|---|---|---|---|
| 20030311 |
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The aim of this study is to asses the effects of the NMDA receptor full agonist D-serine while used as adjuvant treatment for individuals suffering from chronic posttraumatic stress disorder (PTSD). Dysfunction of neurotransmission mediated at NMDA receptor plays a cardinal role in the pathophysiology of PTSD and PTSD patients typically suffer from cognitive dysfunctions and avoidance& depressive symptomatology that may be mediated by NMDA receptor function deficits.
Thus, enhancement of NMDA activity by using D-serine may be beneficial in the treatment of PTSD. The study design involves two 6 week periods during which the participants will be randomly assigned to receive treatment with D-serine (~2g /dy)and placebo. This design allows each participant the opportunity to respond to the experimental treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Placebo Comparator | Adjuvant 6 weeks treatment with placebo (~2g /day) |
|
| 2 | Experimental | Adjuvant 6 weeks treatment with D-serine (~2g /day) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| D-serine (~2g /day) | Drug | Two 6 weeks treatment arms under a cross over design. In one arm adjuvant treatment with experimental medication (D-serine ~2g /day), in the second arm adjuvant treatment with placebo (~2g /day) |
| Measure | Description | Time Frame |
|---|---|---|
| CAPS scores | 6 week treatment |
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Inclusion Criteria:
• Chronic PTSD (DSM-IV diagnosis)
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Uriel Heresco-Levy, M.D | Ezrat Nashim-Herzog Memorial Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ezrat Nashim-Herzog Memorial Hospital | Jerusalem | 91351 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19366490 | Derived | Heresco-Levy U, Vass A, Bloch B, Wolosker H, Dumin E, Balan L, Deutsch L, Kremer I. Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder. Int J Neuropsychopharmacol. 2009 Oct;12(9):1275-82. doi: 10.1017/S1461145709000339. Epub 2009 Apr 15. |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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