Study to Evaluate the Use of Ultrasound in the Diagnosis of Hemophilic Joint Disease

Evaluation of the Role of Power Doppler Sonography in the Diagnosis of Hemophilic Joint Disease

The purpose of this study is to see whether power Doppler sonography (PDS) can be used to diagnose synovitis in patients with inherited bleeding disorders.

Aim #1 - To determine if PDS can be used to diagnose synovial hypertrophy and inflammation in joint disease associated with inherited bleeding disorders. MRI will be used as a reference standard.

Aim #2 - To determine if PDS can be used to assess therapeutic response to treatment.

Aim #3 - To determine if PDS can be used as a screening tool for diagnosing early synovitis.

Inclusion Criteria:

• Diagnosis of inherited bleeding disorder

For Aim 1:

• Age of at least 6 years
• History of at least 4 bleeds in the same joint in the preceding 6 months
• Joint swelling, synovitis or deformity

For Aim 2:

• Meet inclusion criteria for Aim 1 and will be having a synovectomy

For Aim 3:

• Age of at least 1 year
• Have had at least 2 joint bleeds

Exclusion Criteria:

• Not meeting inclusion criteria