Oral Diindolylmethane (DIM) for the Treatment of Cervical Dysplasia

Diindolylmethane (DIM) Dietary Supplementation: A Nonsurgical Treatment for Cervical Intraepithelial Neoplasia (CIN)

To determine if the use of oral Diindolylmethante (DIM), a marketed cruciferous vegetable based dietary supplement (Bioresponse-DIM), is associated with the regression of cervical dysplasia in otherwise healthy women.

To determine if the use of oral Diindolylmethane (DIM), a marketed cruciferous vegetable based dietary supplement (BioResponse-DIM®), is associated with the regression of cervical dysplasia in otherwise healthy women. Additionally, the study aims to see how the use of the BioResponse-DIM supplement correlates with cervical HPV colonization, and to asses the tolerability of daily DIM supplementation

Inclusion Criteria:

• Non pregnant women greater than or equal to 18 years of age able to consent
• CIN II or III confirmed by histology
• Karnofsky performance status >= 80
• No prior treatment for dysplasia in the past 4 months

Exclusion Criteria:

• Incompletely visible lesion
• Diethylstilbestrol (DES) exposure
• HIV seropositive