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| Name | Class |
|---|---|
| Eli Lilly and Company | INDUSTRY |
| Medical Service Line ABRC | UNKNOWN |
| US Department of Veterans Affairs | FED |
This research study helps to demonstrate that adding vitamins and fats (nutritional supplements) to a diet will help reduce body weight and improve the lipid profile. This will be done by examining the body weight and chemicals in the blood. The chemicals are the result of the brain using the fat that subjects eat in their diet. Some medications may also change the amount of these chemicals in a person's blood.
To demonstrate that supplementation of antioxidants and omega-3 fatty acids will improve clinical outcome including cognitive performance in olanzapine treated patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Olanzapine | Active Comparator |
| |
| Omega 3 | Active Comparator |
| |
| Vitamin E +C | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Olanzapine, Omega 3, Vitamin E+C | Drug | No adverse event nor SAE noted. |
|
| Measure | Description | Time Frame |
|---|---|---|
| PANSS | Study completed in 2006. PI no longer with the institution. Study was closed accordingly to the HAC. | 2003-2006 |
| BMI | BMI match height and weight. | 2003-2006 |
| Blood samples | Samples analyzed, PI analyzed and published. PI no longer with the institution. | 2003-2006 |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive assessments | BACS assessment. Data analyzed and published by the PI. | 2003-2006 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Peter Buckley, M.D. | VA MC/Medical College of Georgia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Medical Center | Augusta | Georgia | 30904 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11232752 | Background | Jones B, Basson BR, Walker DJ, Crawford AM, Kinon BJ. Weight change and atypical antipsychotic treatment in patients with schizophrenia. J Clin Psychiatry. 2001;62 Suppl 2:41-4. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D015430 | Weight Gain |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| D000077152 | Olanzapine |
| D004281 | Docosahexaenoic Acids |
| ID | Term |
|---|---|
| D001569 | Benzodiazepines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006571 | Heterocyclic Compounds |
| D015525 | Fatty Acids, Omega-3 |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |