A Study in Subjects With Retinal Detachment

A Double-Masked, Randomized, Dose-Ranging Study of a Single Intravitreal (IVT) Injection of INS37217 Intravitreal Injection in Subjects With Retinal Detachment

The purpose of this trial is to access the tolerability of INS37217 Intravitreal Injection when administered intravitreally in subjects with macula-on or macula-off rhegmatogenous retinal detachment (RRD).

Inclusion Criteria:

• have macula-on or macula-off rhegmatogenous retinal detachment
• are eligible for pneumatic retinopexy, with identifiable retinal breaks
• are phakic or pseudo-phakic

Exclusion Criteria:

• have detachments not of a rhegmatogenous nature
• currently have blood in the vitreous, corneal opacity, or other conditions which limit the view of peripheral retina
• have evidence of intraocular inflammation (uveitis)
• have a history of current condition of uncontrollable, elevated IOP or open-angle glaucoma
• have breaks not conducive to a single procedure of pneumatic retinopexy treatment
• have proliferative vitreoretinopathy of type C or D
• have previously had a vitrectomy or require one
• have previously had a scleral buckle procedure