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| ID | Type | Description | Link |
|---|---|---|---|
| IRB Project Nr. 21/2004 | |||
| HSZ-001 |
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The purpose of this study is to study the feasibility and Toxicity of allogeneic haploidentical hematopoietic cell transplantation with CD3/CD19 depleted stem cells and a dose reduced conditioning.
Transplantation of a CD3/CD19 depleted stem cell grafts after dose reduced conditioning for the treatment of treatment refractory or relapsed hematologic malignancies after preceding allogeneic or autologous hematopoietic cell transplantation.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fludarabine | Drug | |||
| Thiotepa | Drug | |||
| Melphalan | Drug | |||
| OKT-3 | Drug | |||
| CD3/CD19 depletion on CliniMACS | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Engraftment | ||
| Toxicity | ||
| Mortality and Morbidity |
| Measure | Description | Time Frame |
|---|---|---|
| Infections | ||
| GVHD | ||
| Immune reconstitution |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wolfgang A Bethge, MD | University of Tuebingen Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Dresden Medical Center | Dresden | D-01307 | Germany | |||
| Center for Marrow Transplantation |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22491731 | Derived | Federmann B, Bornhauser M, Meisner C, Kordelas L, Beelen DW, Stuhler G, Stelljes M, Schwerdtfeger R, Christopeit M, Behre G, Faul C, Vogel W, Schumm M, Handgretinger R, Kanz L, Bethge WA. Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: a phase II study. Haematologica. 2012 Oct;97(10):1523-31. doi: 10.3324/haematol.2011.059378. Epub 2012 Apr 4. |
| Label | URL |
|---|---|
| Related Info | View source |
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| Disease response |
| Long term toxicity |
| Essen |
| 45122 |
| Germany |
| Medical Center University of Hamburg | Hamburg | 20246 | Germany |
| Medical Center University of Muenster | Münster | 48129 | Germany |
| South West German Cancer Center, University of Tuebingen Medical Center | Tübingen | 72076 | Germany |
| Deutsche Klinik für Diagnostik | Wiesbaden | 65191 | Germany |
| University of Wuerzburg Medical Center | Würzburg | D-97070 | Germany |
| ID | Term |
|---|---|
| D019337 | Hematologic Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| C024352 | fludarabine |
| D013852 | Thiotepa |
| D008558 | Melphalan |
| ID | Term |
|---|---|
| D063088 | Phosphoramides |
| D009943 | Organophosphorus Compounds |
| D009930 | Organic Chemicals |
| D013721 | Triethylenephosphoramide |
| D001388 | Aziridines |
| D001389 | Azirines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D009588 | Nitrogen Mustard Compounds |
| D009150 | Mustard Compounds |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010649 | Phenylalanine |
| D024322 | Amino Acids, Aromatic |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
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