A Study Evaluating the Effects of Nebivolol on Blood Pressure in Hypertensive Patients

A Double-Blind, Multi-Center, Randomized, Placebo-Controlled, Parallel Group Dosing Study Evaluating the Effects of Nebivolol on Blood Pressure in Patients With Mild to Moderate Hypertension

The purpose of this study is to evaluate the effects of various doses of nebivolol in patients with mild to moderate hypertension.

This was a multi-center, randomized, double-blind, parallel group, placebo-controlled study of nebivolol over a range of doses in patients with mild to moderate hypertension. The study consisted of 2 phases: screening/washout/single-blind placebo run-in followed by randomization/double-blind treatment. During the double-blind phase, patients received nebivolol or placebo. Patients had 7 scheduled clinical visits during the study.

Inclusion Criteria:

• An average sitting diastolic blood pressure of greater then or equal to 95 mmHg and less then or equal to 109 mmHg at baseline

Exclusion Criteria:

• Recent myocardial infarction or stroke
• Secondary hypertension
• Contraindications to beta-blocker treatment or discontinuation of current antihypertensive therapy
• Pregnancy, nursing, or women of child-bearing potential not using appropriate contraception