Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Mothers are given the medication oxytocin after birth to help the uterus (womb) contract and therefore reduce blood loss. In Canada, oxytocin is given either into the muscle of the thigh or into a vein. However, it is not known which route is better.This study will test which dose and route of oxytocin is best in reducing blood loss following vaginal delivery.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group B | Active Comparator | women in group B will receive 10 uts oxytocin IM |
|
| group C | Active Comparator | women in group C will receive oxytocin 5 uts IV |
|
| group A | Active Comparator | women in group A will receive oxytocin 5 uts IM |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oxytocin | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in hematocrit |
| Measure | Description | Time Frame |
|---|---|---|
| estimated blood loss | ||
| postpartum hemorrhage (estimated blood loss > 500cc) | ||
| severe postpartum hemorrhage (estimated blood loss > 1000cc) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Colleen L Cook, MD | Resident, Discipline Obstetrics and Gynecology, Memorial University of Newfoundland | Principal Investigator |
| Joan Crane, MD | Faculty, Discipline Obstetrics and Gynecolgy, Memorial University of Newfoundland | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Women's Health Centre, Eastern Health | St. John's | Newfoundland and Labrador | A1B 3V6 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33169839 | Derived | Oladapo OT, Okusanya BO, Abalos E, Gallos ID, Papadopoulou A. Intravenous versus intramuscular prophylactic oxytocin for the third stage of labour. Cochrane Database Syst Rev. 2020 Nov 9;11(11):CD009332. doi: 10.1002/14651858.CD009332.pub4. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| incidence of hypotension |
| length of third stage of labour |
| need for blood transfusion |
| incidence of retained placenta |
| need for dilatation and curettage |
| need for hysterectomy |
| need for additional oxytocics after delivery |
| postpartum antibiotic use |
| maternal satisfaction |
| bleeding needing readmission |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |